Pediatric hematology and oncology, treatment of children with sickle cell disease, central nervous system tumors, late effects of treatment and issues of survivorship
Dr. King’s research focuses on factors that impact a child’s opportunity to learn. From a biological standpoint, she studies how chronic diseases such as sickle cell disease or brain tumors alter cognition. In addition, Dr. King studies the environment’s influence on children’s development and participation. The goal of this work is to determine targets for intervention that will have the greatest impact on development and education. Her methods include psychological and performance-based assessment, environmental assessments via home or public health measures, and epidemiological tools to incorporate medical and social science measures. Dr. King's collaborators are from occupational therapy, pediatrics, public health, education, social work, neurology, psychology and radiology.
2015: PhD, Saint Louis University, Department of Education
2003: MPH, Saint Louis University
2000-2003: Pediatric Hematology-Oncology Fellow, St. Louis Children's Hospital, Washington University School of Medicine in St. Louis
2002-2002: Visiting Fellow, Pediatric Neuro-Oncology, Children's National Medical Center, George Washington School of Medicine, Washington DC, Supervisor: Roger Packer, M.D.
1996-1999: Resident, St. Louis Children's Hospital, Washington University School of Medicine in St. Louis
1996: MD, University of Missouri School of Medicine, Columbia
1992: BS in electrical engineering, Washington University in St. Louis
Dr. King is a pediatric hematologist and oncologist. She focuses her research on educational outcomes of two populations of children with chronic diseases: children with sickle cell disease (SCD) and children with brain tumors. She is investigating variables related to academic achievement and self-sufficiency, including socioeconomic status and family dynamics.
Dr. King earned her BS in electrical engineering at Washington University in St. Louis in 1992, and graduated from medical school at the University of Missouri-Columbia in 1996. After training in a general pediatric residency at St. Louis Children’s Hospital and Washington University School of Medicine, Dr. King was an instructor of pediatrics in newborn medicine before returning to the university for a fellowship in pediatric hematology and oncology. During her fellowship, she also trained at Children’s National Medical Center in pediatric neuro-oncology and earned a Master of Public Health (MPH) from Saint Louis University in 2003. She earned her PhD in Education from Saint Louis University in 2015.
Adolescents with SCD have multiple challenges. In a recent study, it was reported that only 20% of high school-aged students with SCD completed high school in four years. Dr. King’s research is identifying community resources (vocational education, GED classes) to assist these children and their families. These educational and independent living transitions are taking place concurrently with transition to adult medical care.
Dr. King is also working on a public health project to education African Americans about their sickle trait status and is partnering with a local federally-qualified health center and local churches to complete education, trait testing and genetic counseling. Examples of projects Dr. King is working on include developing relationships with community associations to address educational attainment with these chronic diseases and develop programs to identify young adults with chronic diseases and poor educational attainment and referrals to local programs to assist them in obtaining tutoring, GEDs, and vocational rehabilitation. This triage program will eventually contribute to a self-management program for adolescents and young adults with SCD or brain tumors; evaluate educational attainment in children with brain tumors; evaluation daily living activities in children with brain tumors; evaluate executive function and attention in children with brain tumors; exploring the impact of these illnesses on the parents’ stress level or daily activities; and educate adolescents to improve independent living skills.
- Berg C, Edwards DF, King A. Executive function performance on the children's kitchen task assessment with children with sickle cell disease and matched controls. Child Neuropsychology. 2012;18(5):432-48.
- Debaun MR, Sarnaik SA, Rodeghier MJ, Minniti CP, Howard TH, Iyer RV, Inusa B, Telfer PT, Kirby-Allen M, Quinn CT, Bernaudin F, Airewele G, Woods GM, Panepinto JA, Fuh B, Kwiatkowski JK, King AA, Rhodes MM, Thompson AA, Heiny ME, Redding-Lallinger RC, Kirkham FJ, Sabio H, Gonzalez CE, Saccente SL, Kalinyak KA, Strouse JJ, Fixler JM, Gordon MO, Miller JP, Noetzel MJ, Ichord RN, Casella JF. Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure. Blood. 2012 Apr 19;119(16):3684-90.
- Baszis K, Garbutt J, Toib D, Mao J, King A, White A, French A. Clinical outcomes after withdrawal of anti-tumor necrosis factor α therapy in patients with juvenile idiopathic arthritis: a twelve-year experience. Arthritis Rheum. 2011 Oct;63(10):3163-8. doi: 10.1002/art.30502.
- Creach KM, Rubin JB, Leonard JR, Limbrick DD, Smyth MD, Dacey R, Rich KM, Dowling JL, Grubb RL Jr, Linette GP, King AA, Michalski JM, Park TS, Perry A, Simpson JR, Mansur DB. Oligodendrogliomas in children. Journal of Neurooncology. 2011 Aug 13. [Epub ahead of print]
- Mansur DB, Rubin JB, Kidd EA, King AA, Hollander AS, Smyth MD, Limbrick DD, Park TS, Leonard JR. Radiation therapy for pilocytic astrocytomas of childhood.Int J Radiat Oncol Biol Phys. 2011 Mar 1;79(3):829-34. Epub 2010 Apr 24.
- Casella JF, King AA, Barton B, White DA, Noetzel MJ, Ichord RN, Terrill C, Hirtz D, McKinstry RC, Strouse JJ, Howard TH, Coates TD, Minniti CP, Campbell AD, Vendt BA, Lehmann H, Debaun MR. Design of the silent cerebral infarct transfusion (SIT) trial. Pediatr Hematol Oncol. 2010 Mar;27(2):69-89.
- Lim, AN, Lange, BJ, King, AA. Rehabilitation for Survivors of Pediatric Brain Tumors: Our Work has just Begun. Future Neurol. 2010 Jan; 5(1), 135-146.
- Morris B, Partap S, Yeom K, Gibbs IC, Fisher PD, King AA. Radiation-Induced Cerebrovascular disease in childhood cancer survivors. A Children's Oncology Group Report. Neurology. 2009 Oct 7.(E pub ahead of print)
- Armstrong GT, Liu Q, Yasui Y, Huang S, Ness KK, Leisenring W, Hudson MM, Donaldson SS, King AA, Stovall M, Krull KR, Robison LL, Packer RJ. Long-term outcomes among adult survivors of childhood central nervous system malignancies in the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2009 Jul 1;101(13):946-58. Epub 2009 Jun 17.
- Dean JB, Hayashi SS, Albert CM, King AA, Karzon R, Hayashi RJ. Hearing loss in pediatric oncology patients receiving carboplatin-containing regimens. J Pediatr Hematol Oncol. 2008 Feb;30(2):130-4.
- King AA, Noetzel M, White DA, McKinstry RC, DeBaun MR. Blood Transfusion Therapy is Feasible in a Clinical Trial Setting in Children with Sickle Cell Disease and Silent Cerebral Infarcts, Pediatr Blood Cancer, 2008 Mar;50(3):599-602.
- King AA, White DA, McKinstry RC, Noetzel M, DeBaun MR. A Pilot Randomized Education Rehabilitation Trial Is Feasible in Sickle Cell and Strokes. Neurology, 2007 Jun 5;68(23):2008.
- Leonard JR, Perry A, Rubin JB, King AA, Chicoine MR, Gutmann DH. The role of surgical biopsy in the diagnosis of glioma in individuals with neurofibromatosis-1. Neurology. 2006; Oct 24;67(8):1509-12.
- Field JJ, Mason PJ, An P, Kasai Y, McLellan M, Jaeger S, Barnes YJ, King AA, Bessler M, Wilson DB. Low frequency of Telomerase RNA mutations among children with aplastic anemia or myelodysplastic syndrome. J Ped Hem Oncol. 2006; 28(7) 450-453.
- King A, Herron S, McKinstry R, Bacak S, Armstrong M, White D, DeBaun M. A Multidisciplinary Health Care Team’s Efforts to Improve Educational Attainment in Children with Sickle Cell Anemia and Cerebral Infarcts. Journal of School Health, 2006, 76(1)33-37.
- King A, Tang S, Ferguson K, DeBaun MR. An Education Program to Increase Teacher Knowledge About Sickle Cell Disease. Journal of School Health. 2005;75(1):11-14
- Mosse Y, Greshock J, King A, Khazi D, Weber BL, Maris JM. Identification and high-resolution mapping of a constitutional 11q deletion in an infant with multifocal neuroblastoma. Lancet Oncol. 2003 Dec;4(12):769-71.
- Herron S, Bacak SJ, King A, DeBaun MR. The pediatric forum: inadequate recognition of education resources required for high-risk students with sickle cell disease. Archives of Pediatrics & Adolescent Medicine, 2003 Jan 157(1):104.
- King A, Listernick R, Charrow J, Piersall L, Gutmann DH. Optic pathway gliomas in neurofibromatosis type 1: The effect of presenting symptoms on outcome, American Journal of Medical Genetics. 2003 Oct;122(2):95-9.
- King AA, DeBaun MR, Riccardi VM, Gutmann DH. Malignant peripheral nerve sheath tumors in neurofibromatosis 1. American Journal of Medical Genetics, 2000 Aug 28, 93(5):388-392.
- DeBaun MR, King AA, White N. Hypoglycemia in Beckwith-Wiedemann syndrome. Seminars in Perinatology, 2000 Apr, 24(2) 164-171.
- King A, Gutmann DH. The question of familial meningiomas and schwannomas: NF2B or not to be?. Neurology, 2000 Jan, 1154(1):4-5.
Book Chapters and Other
- King AA, DeBaun MR, White, DA. Need for cognitive rehabilitation for children with sickle cell disease and strokes. Expert Rev. Neurotherapeutics. 2008 Feb;8(2):291-6.
- DeBaun M.R. and King A. Clinical Studies in Pediatric Minority Patients. In: Translational and Experimental Clinical Research, Schuster, D. and Powers, W. (Ed.), Lippincott Williams & Wilkins, Philadelphia, 2005, pp. 209-211.
Awards and Honors
2009-present: ASH Scholar Award
2005: ASH Clinical Research Training Institute
2005-2009: Jacob Javits Junior Investigator Award
2003-2006: National Institutes of Health Pediatric Research Loan Repayment Award
2003-2004: American Heart Association Post Doctoral Fellowship Award