Chang, Chih-Hung, PhD

Clinical Interests

  • Clinical outcomes assessment and management across the continuum of care
  • Synthesizing measurement sciences, predictive analytics, evidence-based medicine/practice, and informatics to guide clinical decision making in real time and to improve symptom and disease management over time.
  • Smart learning and testing to improve clinical competencies

Research Interests

  • Ability and competency assessment
  • Patient-reported outcomes (PROs) and health-related quality of life (HRQOL)
  • Item response theory (IRT) and computerized adaptive testing (CAT)
  • Smart testing and learning (STL) – dynamic assessment and tailored education
  • Precision Rehabilitation Outcomes Universal Design (PROUD)

Teaching Roles

Dr. Chang teaches Measurement Theory and Development (OT680.01).


1987: BS in Psychology, National Chengchi University, Taipei, Taiwan
1995: PhD in Research Methodology and Quantitative Psychology, University of Chicago, Chicago, Illinois


Dr. Chang is a psychometrician and health services researcher trained in research methodology and quantitative psychology. His research focuses on the integration of methodology and technology to advance clinical outcomes assessment and management across the continuum of care. Dr. Chang has extensive experience and expertise in patient-centered outcomes measurement and management in diverse populations and settings utilizing item response theory (IRT) and computerized adaptive testing (CAT). He has created a discipline called "Clinical Infometrics" that is a synthesis of measurement sciences, predictive analytics, evidence-based medicine and informatics to guide clinical decision making in real time and to improve symptom and disease management over time. Dr. Chang directs the Psychometrics-Informatics Laboratory (The pi Lab), which aims to integrate advanced psychometrics and evolving informatics to advance our understanding of participation and human health. The pi Lab focuses on the knowledge translation of measurement theory and data science methods to clinical applications. 

Selected Publications

Newman-Griffis, D. R., Desmet, B., Zirikly, A., Tamang, S., & Chang, C. H. Artificial Intelligence for Human Function and Disability. Frontiers in Digital Health, 5, 1282287.

Wang, Y., Wu, D., Chan, A., Chang, C.-H., Lee, V. W. Y., & Nichol, M. B. (2022). Temporal trend of opioid and nonopioid pain medications: results from a national in-home survey, 2001 to 2018. PAIN Reports, 7(3), e1010. doi:10.1097/pr9.0000000000001010

Lau, S. C. L., Baum, C. M., Connor, L. T., & Chang, C. H. (2022). Psychometric properties of the Center for Epidemiologic Studies Depression (CES-D) scale in stroke survivors, Topics in Stroke Rehabilitation.

Gagnon, C. M., Brewington, D. V., Scholten, P. M., Atchison, J., & Chang, C. H. (2019). Impact of Symptom Reporting Agreement on Interdisciplinary Pain Program Participation. Pain Practice, 19(6), 621-632.PMID: 30891911.

Chang, C. H. (1996). Finding two dimensions in MMPI‐2 depression. Structural Equation Modeling: A Multidisciplinary Journal, 3(1), 41-49.

Chang, C. H., & Cella, D. (1997). Equating health-related quality of life instruments in applied oncology settings. Phys Med Rehab: State of the Art Reviews, 11, 397-406.

Leonelli, B. T., Chang, C. H., Bock, R. D., & Schilling, S. G. (2000). Interpretation of a full-information item-level factor analysis of the MMPI-2: Normative sampling and nonpathognomonic descriptors. Journal of personality assessment, 74(3), 400-422. PMID: 10900568

Cella, D., & Chang, C. H. (2000). A discussion of item response theory and its applications in health status assessment. Medical care, II66-II72. PMID: 10982091

Chang, C. H., Cella, D., Masters, G. A., Laliberte, N., O'Brien, P., Peterman, A., & Shevrin, D. (2002). Real-time clinical application of quality-of-life assessment in advanced lung cancer. Clinical lung cancer, 4(2), 104-109. PMID: 14653866

Chang, C. H., Cella, D., Clarke, S., Heinemann, A. W., Von Roenn, J. H., & Harvey, R. (2003). Should symptoms be scaled for intensity, frequency, or both?. Palliative & supportive care, 1(1), 51-60. PMID: 16594288

Chang, C. H., Nyenhuis, D. L., Cella, D., Luchetta, T., Dineen, K., & Reder, A. T. (2003). Psychometric evaluation of the C hicago Multiscale Depression Inventory in multiple sclerosis patients. Multiple Sclerosis Journal, 9(2), 160-170. PMID: 12708812

Chang, C.H., & Gehlert, S. (2003). The Washington Psychosocial Seizure Inventory (WPSI): psychometric evaluation and future applications. Seizure, 12(5), 261-267. PMID: 12810338

Chang, C. H., & Reeve, B. B. (2005). Item response theory and its applications to patient-reported outcomes measurement. Evaluation & the health professions, 28(3), 264-282. PMID: 16123257

Chang CH, Wright BD, Cella D, Hays RD. The SF-36 Physical and Mental Health Factors were confirmed in cancer and HIV/AIDS patients. J Clin Epidemiol 2007; 60(1):68-72. PMID: 17161756

Chang CH, Boni-Saenz AA, Durazo-Arvizu RA, DesHarnais S, Lau DT, Emanuel LL. A System for Interactive Assessment and Management in Palliative Care. J Pain Symptom Manage 2007; 33(6):745-755. PMID: 17360148

Bjorner, J. B., Chang, C. H., Thissen, D., & Reeve, B. B. (2007). Developing tailored instruments: item banking and computerized adaptive assessment. Quality of Life Research, 16, 95-108. PMID: 17530450

Thissen, D., Reeve, B. B., Bjorner, J. B., & Chang, C. H. (2007). Methodological issues for building item banks and computerized adaptive scales. Quality of Life Research, 16, 109-119. PMID: 17294284

Chang, C. H. (2007). Patient-reported outcomes measurement and management with innovative methodologies and technologies. Quality of Life Research, 16(Suppl 1), 157-166. PMID: 17530448

Chang, C. H., Gonzalez, C. M., Lau, D. T., & Sier, H. C. (2008). Urinary incontinence and self-reported health among the US Medicare managed care beneficiaries. Journal of Aging and Health, 20(4), 405-419. PMID: 18372429

Liang, W. M., Chang, C. H., Yeh, Y. C., Shy, H. Y., Chen, H. W., & Lin, M. R. (2009). Psychometric evaluation of the WHOQOL-BREF in community-dwelling older people in Taiwan using Rasch analysis. Quality of Life Research, 18, 605-618. PMID: 19340606

Lin, H. C., Wu, H. C., Chang, C. H., Li, T. C., Liang, W. M., & Wang, J. Y. (2012). A real time online assessment system with modelized architecture on clinical infometrics for patient reported outcomes of prostate cancer. Computer methods and programs in biomedicine, 106(3), 249-259. PMID: 21051098

Lin, J. D., Lin, J. S., Chen, L. L., Chang, C. H., Huang, Y. C., & Su, Y. C. (2012). BCQs: a body constitution questionnaire to assess stasis in traditional Chinese medicine. European Journal of Integrative Medicine, 4(4), e379-e391.

Zheng, Y., Chang, C. H., & Chang, H. H. (2013). Content-balancing strategy in bifactor computerized adaptive patient-reported outcome measurement. Quality of life research, 22, 491-499. PMID: 22538634

Gordon, E. J., Sohn, M. W., Chang, C. H., McNatt, G., Vera, K., Beauvais, N., ... & Ison, M. G. (2017). Effect of a mobile web app on kidney transplant candidates’ knowledge about increased risk donor kidneys: a randomized controlled trial. Transplantation, 101(6), 1167. PMID: 27463536

Book Chapters and Other

Eremenco, S., Chang, C. H., Webster, K., & Cella, D. (2000). Quality of life evaluation in chronic illness across cultures: The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System and its use in India. In Quality of Life in Health & Disease (pp. 69-81). Malalur Printers.

Cella, D., Chang, C. H., & Heinemann, A. W. (2002). Item response theory (IRT): applications in quality of life measurement, analysis and interpretation. In Statistical Methods for Quality of Life Studies: Design, Measurements and Analysis (pp. 169-185). Boston, MA: Springer US.

Chang, C.H. (2003). Psychometrics critical for aging research. The Buehler Center on Aging Newsletter, 18(2):1, 3, 7. (Editorial)

Chang, C. H., Cella, D., & Wright, B. D. (2005). Measurement consistency for different language versions of health-related quality of life instruments. In N Bezruczko (Ed.), Rasch Measurement in Health Sciences (pp. 152-160). Maple Grove, MN: JAM Press.

Chang, C. H. (2005). Item response theory and beyond: Patient-reported outcomes computerized adaptive testing. In Advances in Health Outcomes Research Methods, Measurement, Statistical Analysis, and Clinical Applications (pp. 37-55). Degnon Associates.

Hauser, J.M., & Chang, C.H. (2009). Understanding and designing coordinated cancer care. The Buehler Center on Aging, Health & Society Newsletter, 22(3):1, 11. (Editorial)

Chang, C. H. (2009). Multidimensional pain assessment in geriatric oncology: An innovative approach. In New Directions in Aging Research: Health and Cognition (pp. 75-90). Nova Science Publishers, Inc.

Chang, C. H. (2013). Dynamic pain assessment: an application of clinical infometrics to personalized pain treatment and management. Handbook of pain and palliative care: Biobehavioral approaches for the life course, 121-130.


1988-1992: Century Scholarship, University of Chicago
1992-1993: Teaching Fellowship, University of Chicago
1994-1995: Teaching Fellowship, University of Chicago
2003: Sustained Service Award, Mid-America Chinese American Professional Association
2005: American Cancer Society Trish Greene Quality of Life Manuscript Award (co-author)
2007-present:  Visiting Scholar, China Medical University, Taichung, Taiwan
2009: Exceptional Reviewer, Medical Care, 2007-2008
2009-2012: Principal Investigator Eligible for Continuous Grant Submission (for temporary members with recent substantial review service), National Institutes of Health
2010: Certificate of Professor, Ministry of Education, Taiwan, Republic of China (No. 017519)
2010: Exceptional Reviewer, Medical Care, 2009
2011-2015: Member, Nursing and Related Clinical Sciences (NRCS) Study Section, Center for Scientific Review, National Institutes of Health
2012: Recognized Reviewer, Archives of Physical Medicine and Rehabilitation
2013: Henry B. Betts, MD, Innovation Award, Rehabilitation Institute of Chicago (“TEACH: Tailored Education to Advance Competencies in Healthcare”)
2013: Henry B. Betts, MD, Innovation Award, Rehabilitation Institute of Chicago (SCIENCE: Spinal Cord Injury Evaluation of Neurologic Changes Based on Evidence”)
2013-present: Faculty Affiliate, Center for Health Statistics, University of Chicago
2014: Outstanding Reviewer, Archives of Physical Medicine and Rehabilitation
2017, 2018: Visiting Scholar, Taipei Medical University, Taipei, Taiwan
2018-2020: Principal Investigator Eligible for Continuous Grant Submission (for temporary members with recent substantial review service), National Institutes of Health
Chang, Chih-Hung

Chang, Chih-Hung, PhD

Professor of Occupational Therapy, Medicine and Orthopaedic Surgery

Curriculum Vitae

Phone: (314) 747-7957
Fax: (314) 286-0631
[email protected]

Research Laboratory

Psychometrics+Informatics Laboratory



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